Regenerative Procedures for Peyronie’s Disease

Peyronie’s Disease is a condition characterised by the development of fibrous plaques within the penile shaft, leading to curvature, narrowing, shortening, and sometimes painful erections. It can impair sexual function and confidence. At our clinic, we provide non-surgical, regenerative therapies focused on healing and remodeling scar tissue while preserving or improving natural erectile function and length.

Core Regenerative Treatment Options

1. Shockwave Therapy

Low-Intensity Shockwave Therapy (Li-ESWT) is a frontline regenerative tool. It works by:

  • Delivering acoustic waves directly to the penile plaque

  • Stimulating local blood flow and cellular repair mechanisms

  • Inducing an inflammatory-healing cascade to soften fibrous tissue

Protocol: Weekly sessions for 4–6 weeks during the active (painful or early) phase or in men with lingering symptoms.

Outcomes:

  • Complete resolution of penile pain in many cases

  • Plaque softening and possible modest curvature improvement

  • Potential to avoid surgery when used early

2. Platelet-Rich Plasma (PRP) Injections

PRP is rich in growth factors that promote tissue remodeling and healing.

  • After numbing the skin, PRP is injected directly into the plaque

  • Enhances collagen remodeling and elasticity

  • May improve curvature, texture, and plaque volume

Protocol: One session every 4 weeks for multiple sessions, often combined with traction.

Benefits:

  • Autologous and natural therapy with minimal side effects

  • Improves tissue quality in conditions like lichen sclerosus too

3. Stem Cell Therapy (Advanced/Optional)

Experimental but promising, stem cell therapy uses mesenchymal stem cells derived from fat or bone marrow.

  • Injected into plaque to stimulate cellular regeneration

  • Discussed on a case-by-case basis with regenerative medicine experts

  • Reserved for highly motivated patients with adequate resources

4. Penile Traction Therapy

A crucial mechanical treatment used alongside biological therapies.

  • Gentle, prolonged stretching using a medical-grade traction device

  • Worn for several hours daily

  • Promotes length gain, curvature correction, and girth improvement

Typical Outcome:

  • 10–20 degrees curvature improvement over months

  • Enhanced girth in areas with narrowing or indentation

  • Especially effective when combined with PRP or shockwave

5. Adjunctive Oral Therapies

Although not regenerative per se, certain medications and supplements support therapy:

  • Pentoxifylline: Enhances blood flow; has anti-fibrotic action

  • Vitamin E & Potaba: Historically used; modest benefit but low risk

  • Often used in early or active phase for stabilization

Tracking and Monitoring Progress

  • We document curvature angle via photo documentation or in-clinic Doppler injection.

  • Regular assessment of plaque size, penile pain, and length is done every few months.

  • Duration of regenerative therapy is typically 3–6 months before considering surgical alternatives if needed.

What to Expect

These regenerative options aim to:

  • Halt progression of Peyronie’s

  • Partially or significantly reduce curvature

  • Relieve pain (usually the first symptom to resolve)

  • Improve erection quality and preserve natural length

Each case is assessed individually, and treatment plans are customized based on curvature severity, plaque duration, and patient goals.

FAQs – Regenerative Peyronie’s Therapy

Can Peyronie’s really be treated without surgery?

Yes, especially if caught early. Regenerative treatments like PRP, shockwave, and traction have helped many men avoid surgery. Surgery is typically reserved for extreme or refractory cases.

How much improvement in curvature can I expect?

  • Varies by case, but 20–30% angle reduction is common with traction and PRP.

  • Some achieve near-complete straightening.

  • Combined approaches yield better outcomes than solo therapies.

Can any of these treatments make it worse?

Rarely. PRP and shockwave are safe with low risk. Traction must be done properly—overstretching can cause irritation, but we provide thorough guidance. If done correctly, these therapies are much safer than doing nothing in the active phase.

Will insurance cover it?

  • Most regenerative options like PRP and shockwave are out-of-pocket, as they are still considered investigational.

  • We aim for cost-effective protocols and discuss all pricing transparently.

Is it too late if I’ve had Peyronie’s for years?

Not necessarily. Chronic plaques may still respond to PRP or traction. We focus on realistic goals—such as regaining lost length or reducing deformity for functional intercourse.

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